RESEARCH SHOWS TURMERIC, PIPERINE OTHER FLAVONOIDS AS THERAPY FOR AUTISM

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In recent times, several studies have indicated rise in cases of autism worldwide.

The situation has been associated a combination of genetic and environmental factors including consumption of processed foods during pregnancy; expectant women not getting enough sunshine or rather vitamin D; and ladies exposed to solvent chemicals at work.

Other reported risk factors during pregnancy include certain infections, such as rubella, toxins including valproic acid, alcohol, cocaine, pesticides and air pollution, foetal growth restriction, and autoimmune diseases.In recent times, several studies have indicated rise in cases of autism worldwide.

The situation has been associated a combination of genetic and environmental factors including consumption of processed foods during pregnancy; expectant women not getting enough sunshine or rather vitamin D; and ladies exposed to solvent chemicals at work.

Other reported risk factors during pregnancy include certain infections, such as rubella, toxins including valproic acid, alcohol, cocaine, pesticides and air pollution, foetal growth restriction, and autoimmune diseases.

Controversies surround other proposed environmental causes; for example, the vaccine hypothesis, which has been disproven.

Specific signs and symptoms of autism include: reactions to smell, taste, look, feel or sound are unusual; difficulty adapting to changes in routine; unable to repeat or echo what is said to them; difficulty expressing desires using words or motions; unable to discuss their own feelings or other people’s; difficulty with acts of affection like hugging; prefer to be alone and avoid eye contact; difficulty relating to other people; and unable to point at objects or look at objects when others point to them.

Several studies have shown that early speech therapy or behavioral interventions can help children with autism gain self-care, social, and communication skills.

The study published in GEN: Genetic Engineering and Biotechnology News has identified curcumin in turmeric, piperine in black pepper, flavonoids in green and cannabinoids in Cannabis sativa to have preventive properties against autism and developmental disorders. The study is titled “Plant-Based Therapies for Autism Spectrum Disorders.”
Curcumin

Indian spice turmeric (Curcuma longa) is well known for its protective effects against neurodegenerative diseases and neuropsychiatric disorders, in which the major curcuminoid is curcumin (diferuloyl methane), a nontoxic molecule, able to cross blood–brain barrier.

Also, it is reported to have positive effects on the treatment of autism as curcumin targets several cell signaling pathways, and its effects are as follows: increasing intracellular levels of glutathione, reducing inflammatory components, mitochondrial dysfunction, oxidative/nitrosative stress, and protein aggregation, counteracting the damage caused by heavy metals, and supporting liver detoxification.

Signs of brain toxicity and delayed maturation of brain have been studied in induced autism animal models; curcumin can ameliorate these alterations and is able to improve abnormal brain weight and delayed maturation.

Pharmacokinetic assessments have showed that curcumin bioavailability is high and plasma levels of it increased to their highest levels (184 ng/mL) 80 min after oral administration; amorphous solid dispersion of curcumin has demonstrated enhanced bio-efficiency in 10-fold lower dose.

Piperine

The major alkaloid commonly used for seizure disorders present in Piper longum and black pepper Piper nigrum is piperine. It has been shown to own antioxidant, neuro-protective, anxiolytic, and cognition enhancing effects.

A study reports amelioration effects of piperine on behavioral alterations and oxidative stress markers in autism induced murine model, revealing that piperine treatment restored the motor deficits and decreased the reorientation time, due to its capability to struggle with the induced cerebellar damage by sodium valproate.

 

Piperine also has neuro-protective effects on glutamate at concentration of 20 mg/kg, which induced cell viability restoration. Oxidative stress alterations might be meaningfully reversed by treatment with piperine; besides, a neurobiological finding in ASD is the restoration of the integrity of the cerebellum by a decrease in number of Purkinje cells, which are connected with cerebral cortex and limbic system. Therefore, autism could be a pharmacological condition for biomedical treatment with piperine.
Flavonoids.

 

The researchers found 20 per cent of babies conceived in January and May and 19 per cent of those conceived in December had learning difficulties.

This was higher than the Scottish average of 18.8 per cent, according to the results published in the journal Scientific Reports.

The new study adds more weight to the theory that sunlight and vitamin D play a role, as well as other factors, such as family history, in the development of intellectual disabilities. Vitamin D is considered crucial for a baby’s development; meaning low levels in early pregnancy could affect their brain.

The results show a ‘statistically significant’ relationship between lower UVB exposure over the whole of pregnancy and the risk of learning disabilities.

The academics also found a slightly stronger relationship with low UVB exposure in the first trimester, suggesting that early pregnancy may be the most vulnerable to the effects of insufficient UVB.

Also, a new study suggests women who are exposed to solvents at work are 1.5 times more likely to have a child with autism.

The recent surge in cases of autism suggests that something more than genetic inheritance is at play.

New US National Institute for Occupational Safety and Health (NIOSH) research uncovered a strong link between autistic children and mothers who work industrial jobs that expose them to potent chemicals.

The study authors think that, while these children are still in the womb, they get exposed to the same toxins their mothers are, and it may alter their brain development.

In less than 20 years, the number of eight-year-olds who are on the autism spectrum has more than doubled.

Scientists are fairly certain that genetics have something to do with autism, which is more likely to affect a child who has a sibling on the spectrum.

From there, risk factors are a loose, disjointed network. Autism is more common in boys, children of older parents, and children with intellectual disabilities and most children don’t get diagnosed until after age four, but there’s no cut-off age.

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